Endocrine Abstracts

Objectives: BRAFV600E- anaplastic thyroid cancers (ATCs) show remarkable responses to dabrafenib and trametinib (dab/tram) an effect that may be in part immune-mediated. Murine BRAFV600E-ATCs regress upon BRAF inhibition. We find that recurrences are frequent and associated with loss of Mhc class II (MhcII) expression. Our goal was to investigate the mechanisms of loss of antigen presentation by tumor cells and whether this contributes to disease recurren...

Introduction: Psoriasis is a systemic inflammatory skin disease, which is associated with increased cardiovascular disease (CVD) potentially through metabolic derangements due to chronic inflammation. Serum adiponectin appears to decrease the risk of CVD and has been shown to negatively associate with waist size and insulin resistance (IR), both of which are increased in psoriasis. It is unknown, however, if psoriasis is associated with decreased adiponectin levels beyond trad...